In Yasunari Kawabata’s unsettling short story, Yumiura, a novelist receives an unexpected visit from a woman who says she knew him 30 years earlier. They met when he visited the town of Yumiura during a harbor festival, the woman explains. But the novelist cannot remember her. Plagued recently by other troublesome memory lapses, he sees this latest incident as a further sign of mental decline. His discomfort turns to alarm when the woman offers more revelations about what happened on a day when he visited her room. “You asked me to marry you,” she recalls wistfully. The novelist reels while contemplating the magnitude of what he had forgotten. The woman explains that she had never forgotten their time together and felt continually burdened by her memories of him.

After she finally leaves, the shaken novelist searches maps for the town of Yumiura with the hope of triggering recall of the place and the reasons why he had gone there. But no maps or books list a town called Yumiura. The novelist then realizes that he could not have been in the part of the country the woman described at the time she remembered. Her detailed, heartfelt and convincing memories were entirely false.

Seven different ways that memory can mess with your head and your life, and ways to identify them.

By Daniel Schacter

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A Californian team say they have managed to convert human skin cells directly into functioning brain cells.

The scientists manipulated the process by which DNA is transcribed within foetal skin cells to create cells which behaved like neurons.

The technique had previously been demonstrated in mice, says the report in Nature.

It could be used for neurological research, and might conceivably be used to create brain cells for transplant.

Reprogrammed skin

The scientists used genetically modified viruses to introduce four different "transcription factors" into foetal skin cells. These transcription factors play a role in the "reading" of DNA and the encoding of proteins within the cell.

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“Start Quote

We showed that it is possible to convert human skin cells directly into cells which look and behave like nerve cells”

Marius WernigStanford University

They found the introduction of these four transcription factors had the effect of switching a small portion of the skin cells into cells which functioned like neurons.

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“The people who are the hardest to love are the ones who need it the most.” ~Peaceful Warrior

Editor’s Note: This is a guest post from Celestine Chua of The Personal Excellence Blog.

Have you ever dealt with negative people before? If you have, you will know that the experience can be quite a downer.

I used to have an ex-colleague who was very negative. In our conversations, she would complain endlessly about her co-workers, her work and her life. She was also very cynical about people in general, often doubting their intentions. Talking to her wasn’t a pleasant experience at all.

The first time we had a meeting, I felt very drained. Even though we talked for only 20-30 minutes, I didn’t have the mood or energy to do anything after our conversation. It felt as if someone had sucked the life out of me, and it wasn’t until 2-3 hours later that the effect wore off.

The same thing happened the next few times we talked. Because she was so pessimistic, her negative energy often spilled over after the conversation, leaving me with a bad taste in my mouth. For a period of time, I was quite bothered by her. I would avoid speaking to her if I could.

After a while, I figured I needed to work out an action plan to deal with negative people. After all, she was not going to be the only negative person I was going to encounter in my life. I thought: “For every 1 negative person I face now, there are probably thousands of them out there whom I’ll meet one day. If I learn how to deal with her effectively, I will be able to handle other negative people next time.”

With this in mind, I then brainstormed on the best approach to handle negative people.

Eventually, I developed several key steps to deal with negative people effectively. These steps have proven very helpful in making the best out of my relationships with them. While the people I face today are generally more positive, these steps come in handy when I’ve to deal with a negative person.

If there’s someone negative in your life at the moment, don’t let yourself be affected by him/her. You’re not alone in your problem – I face negative people as well and dealing with them is always a learning experience. While people can try to get you down, you’ve a choice in how you react to them.

Here, I’d like to share my 7 tips on how you can deal with negative people:

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“It is better to take many small steps in the right direction than to make a great leap forward only to stumble backward.” – Old Chinese proverb

Think big. Live to the max. Change the world.

All worthwhile aims, I’m sure you’ll agree. These high-flying statements are meant to encourage us to achieve great things with our lives. But, rather than being an inspiration, do such huge goals just leave you feeling overwhelmed instead?

Sadly, many of us never begin developing new habits because we think a positive outcome will take too much effort. Or else, after we do start to improve our lifestyle, we give up far too soon because we don’t get what we want fast enough. It’s easy to be daunted by the size of the challenge ahead.

I know what it’s like. For 15 long years, I tried again and again to lose weight and get fit. Eventually, I managed to shift nearly 100 pounds – and revamp other aspects of my life – once I realized the most effective way to tackle change is to view it with a small-scale perspective.

Perhaps you’re struggling right now because you’ve set yourself targets that are difficult to reach, however hard you work. Maybe you’re focusing on the distant end result and are about to quit at any moment.

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Although the word contemplative sounds fancy, everyone has been contemplative – you know, looking up at the stars, going to the ocean and getting a sense of the enormity of it all, or looking into your baby’s eyes and thinking, Holy Moly, how did I get you and how did you get me? All of that is contemplative. In addition to that, all the major religions have formal contemplative practices. But people can engage in contemplative activity without framing it in terms of a relationship with God or something like that.

The contemplative tradition I know best is Buddhism. It’s also the contemplative tradition that has had the greatest crossover with Western science; much of the research on meditators has been on Buddhist meditators. Arguably, though, the majority of research has been on those who practice TM, or Transcendental Meditation, which is nested in the Hindu tradition.

The field of contemplative neuroscience is just exploding, in tandem with the explosion of knowledge about brain science in general. People know twice as much about the brain today than they did in 1990, and I’d have to say science knows a hundred times more today than it did in 1990 about what happens in the brain when people engage in contemplative practices.

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